Follicular lymphoma is also called an indolent or lowgrade lymphoma for its slow nature, both in terms of its behaviorslower growthand how it looks under the. The cancer originates from the uncontrolled division of specific types of bcells known as centrocytes and centroblasts. Lymphoma staging the ann arbor staging system, first introduced in 1971 and altered in 1989 to include the cotswolds modifications. No sex preponderance is seen for follicular lymphomas, but the incidence increases with age and varies across racial groups. In clinical practice, a few subtypes of lymphoma account for the majority of cases. This lymphoma subtype accounts for 20 to 30 percent of all nhl cases. History of autoimmune conditions and lymphoma prognosis. Follicular lymphoma current management and novel approaches. Sep 15, 2011 follicular lymphoma fl is the second most common nonhodgkin lymphoma in western countries, with an incidence of 2. Follicular lymphoma is the most common subtype of low grade indolent. Pdf gastrointestinal follicular lymphoma gifl is a relatively rare disease, accounting for only 1%3.
Of the more than 66,000 cases of nonhodgkin lymphoma nhl estimated to have been diagnosed in 2008 in the united states, 1520% were follicular lymphomas. Follicular lymphoma fl is the second most common type of nonhodgkin lymphoma in the united states. Current treatment strategies in follicular lymphomas annals of. Unraveling transformation of follicular lymphoma to diffuse. Our vision is that one day the great majority of people who have been diagnosed with hodgkin lymphoma will be cured or will be able to manage their disease with a good quality of life. This book provides a stateoftheart overview of follicular lymphoma. Fl is characterized by a proliferation of neoplastic gc b cells, both centrocytes and centroblasts, with at least a partial follicular pattern. Splenic involvement by follicular lymphoma this illustration depicts the classic appearance of spleen involved by follicular lymphoma, namely the presence of discrete, miliary, small, white pearly nodules throughout the whole parenchyma. Mar 03, 2020 of the more than 66,000 cases of nonhodgkin lymphoma nhl estimated to have been diagnosed in 2008 in the united states, 1520% were follicular lymphomas.
E lento, pouco agressivo e responde bem ao tratamento mesmo quando descoberto ja em um estagio avancado. Scribd is the worlds largest social reading and publishing site. Fact sheet follicular lymphoma leukaemia foundation. Lnh indolen stadium i dan ii radioterapi memperpanjang disease free survival pada beberapa pasien.
Table 1 summarizes clinical features of the most common lymphoma subtypes. A key at the bottom of each page shows you whether the section has l lymphoma information hl hodgkin lymphoma information nhl nonhodgkin lymphoma information. Review of progress for follicular, sll, diffuse large cell, and mantle cell. Apr 28, 2016 fl is characterized by a proliferation of neoplastic gc b cells, both centrocytes and centroblasts, with at least a partial follicular pattern. Alcohol use disorders identification testconcise auditc brief screen to detecting heavy alcohol use alcohol use disorders identification test audit screen for active alcohol abuse or dependence cage questionnaire 4 question screening for alcohol problems car, relax, alone, forget, friends, trouble crafft 2. The guideline group was selected to be representative of uk. This study aimed to improve our understanding of the genetics underlying fl histological transformation, and to identify genetic drivers or promoters of the transformation by elucidating the differences between fl samples.
Fl is a lymphoma subset that proved fdgavid in more than 95% of the cases. Follicular lymphoma fl is the second most common nodal. Lymphoma begins when healthy b cells, t cells, or nk cells in the lymphatic system change and grow out of control, which may form a tumor. Pdf diagnosis and treatment of follicular lymphoma. Lymphoma is a cancer of a part of the immune system called the lymph system.
An overview of follicular lymphoma verywell health. Follicular lymphoma international prognostic index 2 flipi2 pathogenesis of follicular lymphoma risk factors. If a cancer comes back after treatment it is called a recurrence. The classification of nonhodgkin lymphoma is complex and everevolving, with more than 50 different subtypes listed in the latest world health organization classification. Imaging for staging and response assessment in lymphoma. Rituximab with or without bevacizumab for the treatment of. Follicular lymphoma fl of the gastrointestinal tract, especially duodenal follicular lymphoma dfl, is a rare variant of fl that is defined in the 2008 who classification system. Guidelines on the investigation and management of follicular. People with these types of lymphoma can live nearnormal lifespans, but the disease is incurable.
The british journal of haematology publishes original research papers in clinical, laboratory and experimental haematology. Follicular lymphoma fl is the second most common nonhodgkin lymphoma in western countries, with an incidence of 2. In a prospective cohort study, we evaluated selfreported history of. Nonhodgkin lymphoma is the most common hematologic malignancy, with an estimated 70, cases diagnosed in the united states in 2012. Common symptoms of fl include enlargement of the lymph nodes in the neck, underarms, abdomen, or groin, as well as. Hodgkin lymphoma, so you can work with your healthcare team to determine the best options for the best outcomes. These cells normally occupy the follicles nodular swirls of various types of lymphocytes in the germinal centers of. Follicular lymphoma fl is typically a slowgrowing or indolent form of non hodgkin lymphoma nhl that arises from blymphocytes, making it a bcell lymphoma. Watchful waiting is not a good strategy for everyone, as it leads to significant distress and anxiety in some.
Knowing which type of lymphoma you have is important because it affects. Seom clinical guidelines for the treatment of follicular nonhodgkins lymphoma m. Abstract disease overview follicular lymphoma is generally an indolent b cell. Follicular lymphoma is a cancer that affects white blood cells called lymphocytes. Some patients suffer histological transformation to a more aggressive subtype with poorer prognosis. Medline and embase were searched systematically for publications in english from 19802010 using the key words follicular lymphoma, non. The cell divides again and again, making more and more. Jan 14, 2020 follicular lymphoma is a common type of nonhodgkin lymphoma nhl. Second cancers after nonhodgkin lymphoma cancer survivors can be affected by a number of health problems, but often a major concern is facing cancer again. In addition, the administration of rituximab as maintenance therapy after induction is effective in extending the bene. Follicular lymphoma fl is an indolent but largely incurable disease.
Management of indolent lymphoma in the elderly patient. Dec 23, 2011 the guideline group was selected to be representative of uk. The lymphoma guide has sections with information for all types of lymphoma, for hodgkin lymphoma and for nonhodgkin lymphoma. Food and drug administration fdas approval of the anticd20 antibody rituximab for relapsedrefractory follicular lymphoma in 1997 and for firstline treatment of follicular. Medlineplus en espanol tambien contiene enlaces a sitios web no gubernamentales. It is usually a slowgrowing lymphoma that arises from bcells b lymphocytes, a type of white blood cell. Follicular lymphoma fl is a cancer that involves certain types of white blood cells known as lymphocytes. Nonhodgkin lymphomas begin when a type of white blood cell, called a t cell or b cell, becomes abnormal. This jury found that glyphosate was linked to nonhodgkins lymphoma. Some centers advocate the use of single agent rituximab in the treatment of follicular lymphoma rather than the wait and watch approach. The jury sided with the plaintiffs and found the facts were not in monsantos favor. All other type soflymphoma have a frequency of less than 10%. Abstract disease overview follicular lymphoma fl is generally an indolent b cell lymphoproliferative disorder of transformed follicular center. Lymphoma is a cancer that starts in cells that are part of the bodys immune system.
Nonhodgkin lymphoma an overview sciencedirect topics. Autoimmune conditions are strong risk factors for developing lymphoma, but their role in lymphoma prognosis is less clear. Monsantos lawyers argued that roundup was safe to use. Revised response criteria for malignant lymphoma bruce d. Hodgkin lymphoma is a specific type of lymphoma that is covered in another section of this website.